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Guidelines for Large-Scale Applied Clinical Informatics Research (GLACIeR)

The last decade witnessed dramatic growth in electronic health record (EHR) adoption, from less than 10% to nearly universal, in part due to more than $30 billion of federal government spending. Until recently, EHR implementation was limited to locally developed systems at large, academic healthcare organizations, which enabled extensive customization […]


Clinical Informatics Literacy: 5000 Concepts That Every Informatician Should Know

Clinical Informatics Literacy: 5000 Concepts That Every Informatician Should Know is about all aspects of clinical informatics, a subset of the larger field of biomedical informatics. Clinical Informatics is an applied field that exists at the intersection of the fields of medicine, computer science, information science, anthropology, human factors engineering, cognitive psychology […]


A survey of informatics platforms that enable distributed comparative effectiveness research using multi-institutional heterogenous clinical data

The goal of this manuscript is to help investigators understand why informatics platforms are required and to compare and contrast six, large-scale, recently funded, CER-focused informatics platform development efforts. We identified six generic steps that are necessary in any distributed, multi-institutional CER project: data identification, extraction, modeling, aggregation, analysis, and dissemination.