applied clinical informatics


A survey of informatics platforms that enable distributed comparative effectiveness research using multi-institutional heterogenous clinical data

Comparative effectiveness research (CER) has the potential to transform the current health care delivery system by identifying the most effective medical and surgical treatments, diagnostic tests, disease prevention methods, and ways to deliver care for specific clinical conditions. To be successful, such research requires the identification, capture, aggregation, integration, and […]


Lessons learned from implementing service-oriented clinical decision support at four sites: A qualitative study

OBJECTIVE: To identify challenges, lessons learned and best practices for service-oriented clinical decision support, based on the results of the Clinical Decision Support Consortium, a multi-site study which developed, implemented and evaluated clinical decision support services in a diverse range of electronic health records. METHODS: Ethnographic investigation using the rapid […]


Improving Outcomes with Clinical Decision Support: An Implementer’s Guide, 2cd Edition

Improving Outcomes with Clinical Decision Support: An Implementer’s Guide, 2cd Edition Co-published by HIMSS, the Scottsdale Institute, AMIA, AMDIS and SHM, this second edition of the authoritative guide to CDS implementation has been substantially enhanced with expanded and updated guidance on using CDS interventions to improve care delivery and outcomes. […]


As congressional action looms, eminent informaticists define EHR interoperability

Fortunately, it looks as though we may have the basis of a definition of “open records,” aka interoperability, from two noted medical informaticians, Dean Sittig, professor of biomedical informatics at the University of Texas Health Science Center in Houston; and Adam Wright, a senior scientist in the general medicine division […]


CER Hub: An informatics platform for conducting comparative effectiveness research using multi-institutional, heterogeneous, electronic clinical data

Objectives Comparative effectiveness research (CER) requires the capture and analysis of data from disparate sources, often from a variety of institutions with diverse electronic health record (EHR) implementations. In this paper we describe the CER Hub, a web-based informatics platform for developing and conducting research studies that combine comprehensive electronic […]


What makes an EHR “open” or interoperable?

We have identified 5 use cases that comprise a useful definition of an “open or interoperable electronic health record (EHR).” Each of these use cases represents important functionality that should be available to 1) clinicians, so they can provide safe and effective health care; 2) researchers, so they can advance […]